On July 30, 2007, the Vsauce username was registered on YouTube, by a person who never used the account. On June 24, 2010, Michael Stevens launched the main Vsauce channel. Initially, the channel's programming focused on video games and featured a number of different hosts. However, certain segments such as "IMG!" slowly took over and Michael Stevens became the sole host. The channel then graduated to a mix of information and online activities, and solely educational segments popped up. The educational segments became more popular, and since September 9, 2012, only the solely educational segment (known as DOT) has been presented. According to episode #18 of "LÜT" on the original Vsauce channel, the name "Vsauce" was generated using the fake website generator portion of☀https://www.fakenamegenerator.com/, after he generated the fake website "Vsauce.com" he registered it, and started making videos.
In December 2010, the Vsauce2 (on December 7), and Vsauce3 (on December 24) channels were opened. On July 25, 2012, the WeSauce channel was opened.
Vsauce was one of the fastest growing channels during September 2012. During September 2012, the main Vsauce channel reached one million subscribers. In the same month, Bill Nye appeared in one of the main channel's videos, which focused on the joke, "Why did the chicken cross the road?"
Stevens details in the video A Defense of Comic Sans that the text font Alsina is used by the Vsauce channels because of the close resemblance it has to the handwriting of Nik Guinta, the creator of the Vsauce logo.