MindBlow is a segment where Lieber showcases current inventions that are useful, of significant value to society, or are simply humorous.
BiDiPi (which stands for Build it, Draw it, Play it) is a segment where things that were built and drawn by people from all around the world including Vsauce fans are submitted to Vsauce and the best ones are showcased on the show.
FAK (which stands for Facts And Knowledge) is a segment about trivia.
54321 is a segment where Kevin covers four topics, each having one, two, three, or four things related to each other according to order shown, giving a short summary of each, and then ending with five word problems or riddles.
WAC (Weird Awesome Crazy) is a segment that focuses on people who participate in unusual activities from around the world.
BOAT stands for Best Of All Time, a segment in which Kevin presents lists of, as the segment name implies, the best word plays, best flash mobs, best pranks, etc.
Thought Glass is a segment in which Kevin discusses four quick topics, which become a rebus stating an additional fifth topic.